Description
What is 1V-LSD?
Introducing 1V-LSD (1-valeroyl-lysergic acid diethylamide hemi-L-tartrate) or “Valerie” for short.
Just like 1P-LSD and 1cP-LSD, 1V-LSD is a Lysergamide prodrug based on an Ergoline structure, which means it will share many psychedelic characteristics with LSD-25 in a lab setting and likely works through a similar mechanism of action. A prodrug is basically an inactive compound that becomes active upon ingestion due to chemical reactions during metabolisation.
For further information please read our 1V-LSD Ultimate Guide.
What are the effects 0f 1V-LSD?
While it is still early in the lifespan of 1V-LSD, initial reports suggest very similar effects to LSD and 1cP-LSD. However, there are some key differences that seem to distinguish 1V-LSD from other lysergamides.
The main differences we’ve so far been able to ascertain are:
Longer onset – 1V-LSD seems to take around 2-3 hours for the full effects to take hold. Compared to 1-2 hours (or even shorter) for 1cP-LSD and LSD-25.
Greater visual hallucinations – Many researchers have reported that 1V-LSD produces more intense visuals at lower or comparable doses compared to other lysergamides.
Shorter Duration – Reports show that 1V-LSD has a shorter peak (3 hours) and overall duration (6 hours) compared to 1cP-LSD and LSD 25
Female Entity – Many have reported feeling a strong, warm and calming motherly presence during their research
So why such differing effects?
The most plausible reason seems to be due to the larger molecular mass of 1V-LSD compared to other LSD-25 analogues (and of course LSD itself, which has the smallest molar mass of all lysergamides), which will likely affect how it is metabolized by the body, making it more difficult for the stomach’s enzymes to break it down (hence the longer onset) and producing slightly different results.
Despite a few initial reports of nausea, something that can be common with some lysergamides, almost all researchers view their overall experience of experiments with 1V-LSD as positive.
Testing shows that 150mcg 1V-LSD is comparable to 125mcg 1cP-LSD so please adjust your research accordingly.
All products are strictly for research purposes only and not for human consumption.
Store in a cool, dry place away from sunlight. Lysergamides and Tryptamines should be kept below 20’c where possible
Product Name: 1V-LSD 150mcg Blotters
Other Name(s): 1-Valeroyl-lysergic acid diethylamide hemi-L-tartrate
IUPAC: (8β)-1-pentanoyl-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide hemi-L-tartrate
CAS: N/A
Active Ingredient(s): 1V-LSD L-tartrate (150 mcg)
Other Ingredient(s): Soy based ink, 200 gsm blotting paper.
1V-LSD Clinical data Routes of administration oral Legal status Legal status AU: S8 (Controlled drug) CA: Unscheduled DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act US: Unscheduled (when wasn’t sold for human consumption) UN: Unscheduled Identifiers IUPAC name PubChem CID 162368540 UNII V9TJ3HT283 CompTox Dashboard (EPA) DTXSID801342453 Edit this at Wikidata Chemical and physical data Formula C25H33N3O2 Molar mass 407.558 g·mol−1 3D model (JSmol) Interactive image SMILES InChI 1V-LSD (1-valeryl-D-lysergic acid diethylamide), sometimes nicknamed Valerie, is a psychotropic substance and a research chemical with psychedelic effects.1V-LSD is an artificial derivative of natural lysergic acid, which occurs in ergot alkaloids, as well as being an analogue of LSD.1V-LSD has been sold online until an amendment to the German NpSG was enforced in 2022 which controls 1P-LSD and now 1cP-LSD, 1V-LSD and several other lysergamides. Pharmacology As demonstrated with other N-acylated derivatives of LSD, 1V-LSD is believed to serve as a prodrug for LSD but may also act as a weak partial agonist at the 5-HT2A receptor. Animal studies A Head-twitch response assay in mice found that 1V-LSD has a similar potency to 1P-LSD and 1cP-LSD, with behavioral effects also closely resembling these structural analogs. Chemistry 1V-LSD is the condensation product of valeric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of the indole moiety.Ehrlich’s reagent is used to identify the presence of an indole moiety; the chemical backbone of the lysergamide and ergoline molecules. However, as with other N-acylated lysergamides, 1V-LSD reacts very slowly to Ehrlich reagent and may not give reliable results if the reagent isn’t fresh. Legal position 1V-LSD is not a controlled substance in North America (United States and Canada), unless sold for human consumption in the US.Since March 2nd 2022, 1V-LSD has been under investigation in Sweden and may therefore soon become controlled. 1V-LSD was placed under legal control in South Korea in July 2022 on a temporary but renewable basis. An amendment to the NpSG banned the sale of 1V-LSD in Germany in September 2022. Due to a interpunctation error in the actualised NpSG, the ban never took effect. The law was amended in March 2023, now banning 1V-LSD.
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